Salicylate-induced hyperacusis in rats: Dose- and frequency-dependent effects
نویسندگان
چکیده
منابع مشابه
Effects of the cannabinoid CB1 agonist ACEA on salicylate ototoxicity, hyperacusis and tinnitus in guinea pigs
Cannabinoids have been suggested as a therapeutic target for a variety of brain disorders. Despite the presence of their receptors throughout the auditory system, little is known about how cannabinoids affect auditory function. We sought to determine whether administration of arachidonyl-2'-chloroethylamide (ACEA), a highly-selective CB1 agonist, could attenuate a variety of auditory effects ca...
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Stress has an important role in the induction of gastroduodenal injury. It was reported that oxygen free radicals played a role in the pathogenesis of this injury. Although some other antioxidant compounds and calcium channel blockers were examined in ulcer models, salicylate has not been tested for its gastroprotective effect in ulcer models by now. In the present study, intraperitoneal admini...
متن کاملSalicylate-Induced Hearing Loss and Gap Detection Deficits in Rats
To test the "tinnitus gap-filling" hypothesis in an animal psychoacoustic paradigm, rats were tested using a go/no-go operant gap detection task in which silent intervals of various durations were embedded within a continuous noise. Gap detection thresholds were measured before and after treatment with a dose of sodium salicylate (200 mg/kg) that reliably induces tinnitus in rats. Noise-burst d...
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15 صفحه اولStatins Induced Nephrotoxicity: a Dose Dependent Study in Albino Rats
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ژورنال
عنوان ژورنال: Hearing Research
سال: 2017
ISSN: 0378-5955
DOI: 10.1016/j.heares.2017.04.004